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Susan Pfeffer

Celia Schiffer

The National Academy of Sciences recently elected 144 new members, including two ¾«Æ·¹ú²úÒ»Çø¶þÇøÌÒÉ« members, Suzanne Pfeffer and Celia Schiffer. These scientists are being recognized for their distinguished and continuing achievements in original research.

Pfeffer is a professor of biochemistry at Stanford University School of Medicine. Her focuses on understanding the molecular basis of inherited Parkinson's disease, with a specific interest in LRRK2 kinase mutations and the Rab GTPases. The Pfeffer lab is also interested in cholesterol transport and how mutations in this pathway can lead to Niemann–Pick disease. Pfeffer is a past president of ASBMB. She is a fellow of the American Association for the Advancement of Science, the American Academy of Arts and Sciences and the American Society for Cell Biology.

Schiffer is a professor and the chair of biochemistry and molecular biotechnology and the director of the institute for drug resistance  at the University of Massachusetts Chan Medical School. Her focuses on the molecular basis of drug resistance, studying how mutations in drug target enzymes allow them to continue to process their substrates but avoid binding inhibitors. Through this effort, she has defined what she calls the “substrate envelope,” which allows her lab and others to use structure-based drug design to design robust inhibitors that are less apt to be susceptible to resistance. Schiffer received the ASBMB in 2020 and is a fellow of the American Academy of Microbiology.