Webinars
Chemical approaches to sorting out histone modifications
August 13, 2025 | 12:15–1 p.m. Eastern | Free registration required
Speaker
Professor, Brigham and Women’s Hospital/Harvard Medical School
Phil Cole graduated from Yale in 1984, spent a year as a Churchill Scholar at Cambridge, and then obtained M.D. and Ph.D. degrees from Johns Hopkins in 1991. He pursued post-doctoral training at Harvard Medical School prior to joining Rockefeller in 1996 as a junior lab head. In 1999, Cole returned to Johns Hopkins as professor and director of pharmacology until 2017, when he moved to his current position as professor of medicine and biological chemistry and molecular pharmacology at Harvard Medical School and where he serves as chief of the division of genetics at Brigham and Women’s Hospital.
The ASBMB Breakthroughs webinar series offers a window into the cutting-edge biochemistry and molecular biology research driving discovery.
Histone modifications are critical in regulating chromatin and gene expression. Dysregulation of histone modifications can result in various diseases including cancer and various agents are in development to provide therapeutic strategies. We will describe our use of protein semisynthesis and other methods to characterize the influence of individual and combinations of histone modifications on enzyme recognition and processing. We will highlight the use of enzyme engineering to reveal new insights into Lys modification crosstalk.
This webinar is brought to you by the , an ASBMB Journal.